Using this method, they found that a combination of failures—from the partial loss of an essential protein to weakened connections between chromosomes—can cause errors that increase with maternal age.

The current study shows that cells with additional chromosomes have an altered mitochondrial structure and function. The reason: mitochondrial precursor proteins are sequestered in p62-positive ...

DENVER -- Genetic testing and algorithms revealed that over 1% of more than 96,000 blastocyst-stage embryos had ploidy abnormalities, or atypical numbers of chromosomes. In total, ploidy abnormalities ...

The above representative microscope images showcase ultra-fine bridges, a kind of abnormal link between chromosomes that causes catastrophic genetic instability. These bridges, composed of entangled ...

JA Rosenfeld is an employee of Signature Genomic Laboratories, a subsidiary of PerkinElmer, Inc. The authors have no other relevant affiliations or financial involvement with any organization or ...

Carfilzomib or bortezomib with lenalidomide, and dexamethasone (VRd) for initial therapy of newly diagnosed multiple myeloma (NDMM): Long-term follow-up of the ECOG-ACRIN ENDURANCE phase 3 trial. Real ...

Of the nine children born to Joseph and Rose Kennedy, one is President of the U.S., but Daughter Rosemary, 44. has spent half of her life in a special nursing home because she is mentally retarded.