The latest research published in Genes & Diseases unveils groundbreaking insights into the role of the aging process and the ...

The authors show that mouse or human tumours in which the PI3K/Akt pathway is constitutively activated are resistant to dietary restriction whereas other tumours are sensitive. The authors also ...

Gene set comparison analyses of gene expression signatures for the acquired chemotherapy resistance. Background: The PI3K/AKT/mTOR signaling pathway is a central network in a number of cancers, ...

Upon activation by receptor tyrosine kinases, p110 subunits of Class 1A are relieved of their intermolecular inhibition mechanism (ie, interaction with the p85 subunit of PI3K), and PI3K is ...

The latest research published in Genes & Diseases unveils groundbreaking insights into the role of the aging process and the ...

Background: PI3K pathway activation is associated with primary resistance of trastuzumab in patients with HER2-positive metastatic breast cancer. It remains to be not fully understood how this pathway ...

This finding suggests these cancers may have been driven by tamoxifen-induced activation of the phosphatidylinositol 3-kinase (PI3K) pathway, researchers concluded. Data derived from Kubler K, et ...

Gliomas are among the deadliest brain tumors, with limited treatment options and poor survival rates. Scientists from China ...

Combination of PI3-kinase and PARP Inhibitors May Offer New Treatment Option for Triple-negative Breast Cancers November 12, 2012 PI3-kinase inhibitors sensitized tumors to PARP inhibitors.

In short, preclinical models may not necessarily permit the detection of context-specific activation of PI3K (or other effectors) by mutant KRAS.

They are also looking into other ways drugs that activate PI3K could treat other types of nerve damage, including that from spinal cord injury, stroke and neurodegenerative diseases.