The authors show that mouse or human tumours in which the PI3K/Akt pathway is constitutively activated are resistant to dietary restriction whereas other tumours are sensitive. The authors also ...

The latest research published in Genes & Diseases unveils groundbreaking insights into the role of the aging process and the ...

Activation of the PI3K signaling pathway is highly regulated. PI3K activation is initiated by activated receptor tyrosine kinases such as ErbB family receptors, fibroblast growth factor receptors, ...

A pairing of two experimental drugs inhibits tumor growth and blocks drug-induced resistance in ovarian cancer, according to ...

Gene set comparison analyses of gene expression signatures for the acquired chemotherapy resistance. Background: The PI3K/AKT/mTOR signaling pathway is a central network in a number of cancers, ...

This finding suggests these cancers may have been driven by tamoxifen-induced activation of the phosphatidylinositol 3-kinase (PI3K) pathway, researchers concluded. Data derived from Kubler K, et ...

Upon activation by receptor tyrosine kinases, p110 subunits of Class 1A are relieved of their intermolecular inhibition mechanism (ie, interaction with the p85 subunit of PI3K), and PI3K is ...

The latest research published in Genes & Diseases unveils groundbreaking insights into the role of the aging process and the ...

In short, preclinical models may not necessarily permit the detection of context-specific activation of PI3K (or other effectors) by mutant KRAS.

PI3-kinase inhibitors sensitized tumors to PARP inhibitors. ... DNA damage would occur due to BRCA protein downregulation, and that this resulted in activation of PARP to repair the damage. ...

PI3K Inhibitors have emerged as a popular treatment for hormone-receptor-positive breast cancers, improving progression-free survival rates for those with ER+ breast cancer.