Two newly identified disease-causing genes, known as Bzw2 and Eif5a2, have been implicated in early prostate cancer ...

Pten, a major tumor-suppressor, functions to reverse the accumulation of Akt-activating phospholipids produced by PI3K. Pten-inactivating mutations allow excessive activation of Akt. The upshot of ...

A group of such cells, called disease-associated hepatocytes (daHeps), showed NRF2 and AKT activation ... Intriguingly, the mutations observed in MASH-induced HCC are indicative of single-stranded ...

Exon 19 mutations characterized ... However, activation of the Ras–MAPK pathway has not been as well correlated with response to EGFR inhibitors as the PI3K–Akt pathway 158.

AstraZeneca has claimed FDA approval for its first-in-class pan-AKT inhibitor capivasertib ... AKT1, or PTEN mutations. It can be used in patients whose disease has progressed despite prior ...

Funded by Prostate Cancer UK, the ICR team focused on genes involved in the PI3K-AKT pathway, which is frequently mutated in ...

We have shown that tumors with HER2 amplification or PI3K mutation are selectively ... increases their activation and expression, attenuating the antitumor benefit of the drugs. We have shown that ...