All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive inhibitor of ...
Eicosanoids are a class of bioactive lipid mediators derived primarily from arachidonic acid and other polyunsaturated fatty acids. Their metabolism involves a series of enzymatic reactions – chiefly ...