Although chimeric antigen receptor T-cell therapy has raised hopes for long-term remission in autoimmune disease, it has ...

However, the immunotherapeutic can also be used to treat autoimmune diseases by targeting autoreactive B cells. Candid has been pumping money into deals over the past year as it aims to become a ...

Blocking of IL-7R inhibited the upregulation of RAG expression by autoreactive B220 low B cells, thereby preventing receptor revision following antigen recognition. The ability to prevent the ...

In collaborative work, Trethera and the Peter Clark Lab at UCLA have shown that when autoreactive T and B cells divide, they activate the TRE-515 target dCK. In those abnormally activated cells, dCK ...