One of humanity's most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic ...

It has been thought that in the first step in B cell activation, when these immune cells recognize an infectious pathogen, an antigen from that pathogen had to bind to multiple receptors on the ...

If you live in the United States, odds are high that a tiny passenger rides in your blood. By adulthood, more than 94 percent ...

Using a single-cell RNA-sequencing platform, a new study demonstrates that EBV reprograms autoreactive B cells to drive lupus autoimmunity.

Barr virus transforms B cells into inflammatory drivers that spark the widespread immune attacks seen in lupus.

Researchers have created a radical new view of how immune cells recognize threats such as viruses. The discovery could be used to design better vaccines and to gain a deeper insight into autoimmune ...

In vitro studies have suggested that BTKi therapy can suppress NOTCH1 activation via B-cell receptor–NOTCH1 interactions, providing a mechanistic rationale for these clinical results.

B cells are thought to play a critical role in innate and adaptive immunity, but their exact role in anti-tumor immunity remains unknown. Researchers with expertise in immunology collaborated with ...

Findings showed fenebrutinib significantly reduced relapses vs teriflunomide in RMS and was noninferior to ocrelizumab in slowing disability progression in PPMS. Topline data were announced from two ...

The combination of glofitamab (Columvi) plus polatzumab vedotin (Polivy) demonstrated high efficacy and durable responses in patients with relapsed/refractory large B-cell lymphoma (LBCL), according ...