The Scientist

Blocking a B Cell Switch Could Halt Lupus Autoimmunity

Researchers identified a key receptor that primes the formation of autoreactive B cells. Disrupting this pathway may be a ...
ascopubs.org

YF550-C1, an E3 ligase inhibitor of CBL-B, to demonstrate T cell and NK cell activation and anti-tumor activities in syngeneic and PDX tumor model.

An exhaustive pre-clinical study of a circRNA drug candidate (cmRNA1210) encoding IL-12sc for anti-tumor therapeutics. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This ...
Science Daily

Uncovering a way for pro-B cells to change trajectory

Researchers from the School of Veterinary Medicine and Perelman School of Medicine have found that YY1 knockout pro-B cells can generate T lineage cells helping B cells produce antibodies. Development ...
News Medical

The roles of soluble B-cell maturation antigen in targeted immunotherapies

B-cell maturation antigen (BCMA) is encoded by the TNFRSF17 gene found on the short arm of chromosome 16. BCMA is a type III transmembrane glycoprotein primarily expressed on the surface of myeloma ...
Healio

‘Complete eradication’ of B cells drives remission after autoimmune CAR T-cell therapy

Please provide your email address to receive an email when new articles are posted on . A “complete eradication” of B cells with chimeric antigen receptor T-cell therapy is responsible for the ...