With declining SARS-CoV-2-specific antibody titers and increasing numbers of spike mutations, the ongoing emergence of Omicron subvariants causes serious challenges to current vaccination strategies.
To assess the antigenicity of the BA.2.86 spike, we constructed vesicular stomatitis virus (VSV) pseudotyped viruses using both versions of the spike gene as well as BA.2, XBB.1.5 and EG.5.1 ...
Of additional concern, BA.2.75 may differ antigenically from BA.2. The receptor-binding domain of the spike (S) protein of SARS-CoV-2 is capable of inducing neutralizing antibodies and is the major ...