The researchers outfitted CD4+ T cells with synthetic Notch (synNotch ... Their results were clear: a single-cell system carrying TGFβ1 and CD25 significantly outperformed the two-cell approach, ...
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Engineered immune cells may be able to tame inflammationThe team adapted the suppressor cells' anti-inflammatory abilities to work in CD4 immune cells ... then produce TGF-Beta and CD25, molecules that can muzzle killer T cells. They introduced ...
The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...
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