Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

"Very lame and imperfect theories are sufficient to suggest useful experiments which serve to correct those theories and give birth to others more perfect. These, then occasion farther experiments ...
The Scientist

The COX Continuum

The discovery of cyclooxygenase (COX) isoforms, COX-1 and COX-2, in the early 1990s helped explain how non-steroidal anti-inflammatory drugs (NSAIDs) work and led to specific agents with fewer ...
Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...