Human egg cells are often prone to chromosomal errors. As women age, the error rate increases sharply — and can contribute to infertility, pregnancy loss, and ...

Genetic data from 139,416 human embryos were used to characterize chromosomal abnormalities, called aneuploidies, that underlie many cases of pregnancy loss. This approach revealed a relationship ...

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs). What is ...

The vast dataset allowed the Johns Hopkins University-led team to demonstrate robust connections between specific variations in a mother's DNA and their risk of miscarriage. The findings shed new ...

Researchers at the Texas A&M School of Veterinary Medicine & Biomedical Sciences (VMBS) have received a $640,000 grant from the United States Department of Agriculture (USDA) to study abnormalities in ...

The spectrum of information that can be obtained by prenatal testing is wide and rapidly increasing. Many mutations, or "abnormalities," are inconsequential, while others are significant. Genetic ...

Using this method, they found that a combination of failures—from the partial loss of an essential protein to weakened connections between chromosomes—can cause errors that increase with maternal age.