The class of drugs known as DNA Damage Response inhibitors, which work by blocking cancer cells’ ability to repair their own damaged DNA, is expanding rapidly beyond its original anchor, the PARP ...

BioMedWire Editorial Coverage: Oncology research is moving through one of its most active stretches in years. DNA Damage Response ('DDR”) inhibitors, a category of drugs that work by blocking cancer ...

Researchers from the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee, together with collaborators from ETH Zürich, the Malopolska Center of Biotechnology and the ...

Pancreatic cancer is one of the deadliest cancers and the third-leading cause of cancer-related death in the United States.

Hyperreactivity of the gene responsible for DNA repair may indicate a hidden vulnerability of oncological diseases and help ...

Scientists have discovered that a gene normally considered a DNA-protecting "good guy" can become dangerous when cells make too much of it. The gene, EXO1, acts like molecular scissors that help ...

Targeted DNA editing by CRISPR technology has great potential for applications in biotechnology and gene therapy. However, precise gene editing remains a challenge largely due to insufficient control ...

Researchers have captured the first atomic-level views of human SMUG1, a key enzyme involved in repairing damaged DNA.

Newborn nerve cells must squeeze through crowded, narrow spaces—through dense tissue, past other cells, and between fibers—to ...

The base excision repair pathway protects DNA from base damage via oxidation, deamination, alkylation and methylation. DNA glycosylases are key enzymes that recognize damaged bases in a ...

Migrating newborn neurons suffer routine double-strand DNA breaks from physical stress during brain development.

Scientists discovered a protein that helps plants repair DNA damage from sunlight, which could improve future crop gene ...