These unique, branched molecules help LNPs break through the endosomal membrane, making them more effective at delivering mRNA and gene-editing tools. In a study in Nature Communications ...

Exosomes, the small extracellular vesicles secreted by nearly all cell types, have emerged as powerful players in intercellular communication and potential biomarkers for disease diagnosis and therapy ...

Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradatio ...

How is plasma membrane protein composition controlled? There are several control mechanisms, most of which depend on endosomal trafficking pathways. Plasma membrane proteins reach the endosomes by ...

A team led by UT Southwestern Medical Center researchers has identified a key mechanism responsible for endosomal recycling in cells, a process critical to human health. Their findings, published in ...

First, the authors showed that, after entering endosomes, PEI induces endosomal membrane damage and recruits LC3C, an essential protein in the formation of autophagosome. Next, they assessed ...

Researchers at UT Southwestern identified how SNX17 and Retriever interact to regulate endosomal recycling, a crucial process for protein transport. Using cryo-EM imaging, they revealed a key binding ...