The authors further proceed to dissociate the interactions of FoxP3 with cofactors from its DNA-binding ability. While at least two of the hypomorphic mutants show attenuated binding to the genome, as ...

Figure 2: Models for FOXP3-mediated regulation of T-cell activation. On the basis of these data, FOXP3 has both direct and indirect effects on T-cell activation. The direct effects are on the ...

Regulatory T cells are specialized immune cells that suppress the immune response and prevent the body from attacking its own cells. Understanding how these cells work is key to determining how they ...

The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues. More than two decades ...

Thanks to regulatory T cells (Tregs), the immune system is kept in line via a careful system of checks and balances. Immune response too light? A viral infection spreads throughout the body. Immune ...

Researchers determined the Foxp3 protein is actually a cofactor, hijacking DNA-binding proteins responding to the immunological environment of the T cell. Based on the type of response needed, ...

TBCRC009: A multicenter phase II study of cisplatin or carboplatin for metastatic triple-negative breast cancer and evaluation of p63/p73 as a biomarker of response. Background: Predictive markers of ...

Osaka, Japan – The immune system is tightly regulated to ensure that it only responds to actual health threats, instead of attacking our own bodies, which happens in cases of autoimmunity. Now, ...

This is a preview. Log in through your library . Abstract The Foxp3 protein is a specific marker of CD4⁺CD25⁺ regulatory T ($T_{reg}$) cells, and its expression ...

Fine-tuning a gene centrally involved in regulating the immune system offers potential clues for future autoimmunity and cancer treatments. The immune system faces a delicate balancing act: it must be ...