Researchers have found that inhibiting one step of prostaglandin synthesis specifically in macrophages appears to have cardiovascular benefits, an ironic new twist on the relationship between ...
Figure 1: An overview of prostanoid synthesis and prostaglandin receptor affinity. In this Perspectives article, we describe the role of prostanoids in bladder physiology, summarize the findings from ...
Prostaglandins play a role in numerous biological processes, including sleep, pain, fever, inflammation, menstruation, birth, constriction of blood vessels, and blood clotting. The prostaglandin ...
BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...
As indicated earlier, COX proteins are generally believed to be membrane bound; COX-1 is localized primarily in the ER while COX-2 is localized in both the ER and nuclear envelope. However, this ...
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