Cunningham is showing why he’s considered a generational talent, averaging 26.6 points and 9.7 assists, second-best in the NBA. If Detroit were at full health, this would be a great regular-season matchup. However, Pistons starters Jalen Duren and veteran Tobias Harris will be out for this contest.

Tipoff from Little Caesars Arena in Detroit is at 7 p.m. ET. New York is a 1.5-point road favorite, while the over/under is 232.5 in the latest Knicks vs. Pistons odds. Before making any Pistons vs. Knicks picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

Preview the New York Knicks' NBA matchup with Detroit, including betting odds, tips, trends, and game information.

Mickey Mouse and Goofy gave the Cavaliers and Knicks pregame speeches as part of ESPN's animated alternative broadcast.