Leukotriene modifiers (leukotriene antagonists) are medicines used to manage allergic rhinitis or allergies, as well as prevent asthma. These novel drugs work by blocking the action of leukotrienes.

Inflammation and its timely resolution represent a vital physiologic response to infection, injury, and “sterile provocation” by endogenous stimuli. There is a growing appreciation that the initiation ...

Patients with asthma who have aspirin sensitivity have greater cysteinyl leukotriene production and greater airway hyperresponsiveness to the effects of inhaled cysteinyl leukotrienes than their ...

Scleroderma interstitial lung disease (SLD) is a leading cause of morbidity and mortality in patients with systemic sclerosis. Although the pathogenesis of SLD is not clear, excessive fibrosis and ...

Cysteinyl leukotrienes are established mediators of bronchial asthma and have agonist roles analogous to those of histamine in allergic rhinitis. We now know that the substance originally termed ...

Asthma may not be driven by the molecules scientists have blamed for decades. Researchers have identified “pseudo leukotrienes,” inflammation-triggering compounds formed by uncontrolled free-radical ...

For decades, scientists have thought they understood the biochemical machinery that causes asthma—inflammation in the lungs that constricts airways and makes it hard to breathe. Molecules called ...

Scientists have uncovered a surprising new pathway behind life-threatening food allergies. Instead of histamine, a different chemical called leukotrienes drives severe reactions in the gut. These ...

In the study, "Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens," published in Science, researchers combined bulk and single‑cell RNA sequencing, in ...

For those with severe food allergies, just one morsel of the wrong thing can lead to a life-threatening reaction. A new understanding of how this begins could lead to better treatments, a study claims ...

Allergies occur when the immune system treats a harmless foreign protein as an invader. The immune system mounts a full-scale response to the protein. This response involves releasing inflammatory ...