In recent years, non-viral methods for cell engineering have emerged as promising alternatives to viral transduction. Amongst the virus-free technologies, electroporation is considered the gold ...
Kunwoo Ryan Lee, PhD, knew as early as 2012 that solving the delivery problem would be crucial in fulfilling the promise of the newly discovered CRISPR-Cas9 gene editing technology. He felt strongly ...
A major driver of the CRISPR delivery devices market is the growing limitation of viral vector-based delivery systems in large-scale manufacturing. While viral transduction has historically enabled ...
Developers are increasingly exploring non-viral gene therapy delivery methods as safety concerns over viral vectors grow. Approaches such as lipid nanoparticles, Sleeping Beauty transposons, and ...
Safe and redosable expression of DNA into the liver of pig and non-human primate models. Non-viral delivery and expression into genetic pig models of tyrosinemia and phenylketonuria showing ability to ...
SOUTH SAN FRANCISCO, Calif., May 05, 2026--(BUSINESS WIRE)--SonoThera, a biotechnology company developing next-generation genetic medicines to address the root causes of disease, today announced ...
Mounting safety concerns over viral vector-based gene therapies, including liver toxicity and patient deaths, are accelerating interest in non-viral delivery systems. Lipid nanoparticles, Sleeping ...
This article is based on a poster originally authored by Yongyang Huang, Ning Guo, Mackenzie Pierce, Leo Chan, Bo Lin and Yi Yang, which was presented at ELRIG Drug Discovery 2024 in affiliation with ...
An enduring challenge for the commercialization of genetic therapies is delivering the therapeutic molecules to the proper destination within the body. Viruses are natural delivery systems for nucleic ...
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