The anti-tumor immune response involves a series of complex steps mediated by various immune cells and signaling molecules.

A new multi-pronged antibody design could help immune cells receive stronger activation signals against cancer. Researchers ...

Every time our body encounters a new disease-causing agent, a crucial defense system called adaptive immunity comes into play ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 5 (February 1, 2022), pp. 1-3 (3 pages) C. Liu, Y. Zhang, C. C. Liu, D ...

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity. This review synthesizes emerging mechanistic evidence showing that ...

One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T persistence and function. Additionally, there is a growing trend towards ...

Immune checkpoint inhibitors, popularized by Allison and Honjo’s Nobel Prize, were one of the first cancer immunotherapies that gained FDA approval. In the 1990s, Allison and Honjo identified the ...

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of Type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice. In these autoimmune diseases ...