Cell Research - Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells. Skip to main content.

A recent study published in Genes & Diseases reveals new insights into the relationship between immune cell characteristics, ...

Hoffmann, et al. Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol 2009; 39 (4): 1088-1097.

Purpose To characterize the number and functional status of CD4+CD25+ regulatory T cells (Tregs) in patients with metastatic melanoma (MM) and renal cell carcinoma (RCC) treated with high-dose bolus ...

In vitro studies have characterized avidity-mediated binding of INV322 to these tumor Treg antigens as well as an ... INV322 is a next generation anti-CTLA-4 x CD25 bispecific mAb developed using ...

The IL-2/S4B6 complex prevented IL-2 from binding to its high-affinity receptor, CD25, on Tregs, leading to the preferential expansion of IFN-γ–producing T cells and worsening meningeal inflammation.

Advanced imaging technologies are uncovering surprising roles for CD8+ T cells—not just in immune defense, but also in supporting tissue repair and regeneration.

In vivo EGL-001 preferentially bound to the surface of Tregs due to their high CTLA-4 and CD25 expression and depleted them from the tumor microenvironment without affecting other immune cells.

A recent study published in Genes & Diseases reveals new insights into the relationship between immune cell characteristics, ...

In addition to the above-described strategies that target the Treg population directly, indirect approaches can also be taken to enhance Treg function in patients with autoimmune disease. These ...

Secondary Endpoint (Treg Cell Populations): There was a significant increase (p < 0.05) in the percentage of CD4+ FOXP3+CD25 high Tregs, mean fluorescence intensity (MFI) of Foxp3, Treg CD25 MFI ...