Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 12 (Mar. 21, 2006), pp. 4392-4397 (6 pages) A self-catalyzed, site-specific guanine-depurination activity ...

Depurination of DNA and RNA sequences is an alteration of the sugar-phosphate backbone in which hydrolysis of a purine base (adenine or guanine) occurs. Synthetic oligonucleotides suffer from such ...

Spirals of DNA, once thought to be merely the passive memory banks that preserve life’s blueprints, may also actively modify themselves under certain conditions, according to Princeton University ...

(Nanowerk Spotlight) DNA is constantly being damaged in our cells by radiation and other random sources. There is a long list of structural and chemical variations to DNA that have impacts on human ...