Pheiron and Ribo are excited to announce that the first two strategic collaboration milestones have been successfully ...

As a molecule, siRNA goes against just about every rule in the traditional drug discovery book. Compared with small molecules, siRNA is large, covered in negative charges, and doesn’t easily cro ...

The first siRNA drug, patisiran, was approved by the U.S ... Potential to make siRNA drugs work better The discovery led the MSK researchers to partner with colleagues from the Icahn School ...

Multidrug-resistant bacteria pose a major threat to human health. Manipulation of bacterial genes at the transcriptional level is a potential strategy to fight antibiotic-resistant bacterial ...

Prof. Dr. Olivia Merkel, Professor of Drug Delivery, explained: “Nanoencapsulation is a highly efficient way to deliver siRNA to targets across the cellular membrane, protecting it from degradation ...

In a recent publication in Cell Reports Medicine, a collaborative research team led by Chen-Yu Zhang and Huan Wang at Nanjing ...

and to CRISPR and siRNA perturbations, among other examples. These studies are the first steps to validate the use of digital twins in drug discovery, setting the stage for more widespread ...

The first siRNA drug, patisiran, was approved by the U.S ... that's not connected to its normal role in heme synthesis." The discovery led the MSK researchers to partner with colleagues from ...

Materials & Methods: The NDS consisted of cationic liposomes (carrier, 100–140 nm), doxorubicin (DOX, anticancer drug), siRNA targeted to MRP1 and BCL2 mRNA (suppressors of pump and nonpump ...

“We founded Aro with the vision to create a new class of targeted siRNA medicines to address ... with an extensive background in drug development, from discovery through approval, and a robust ...