Two newly identified disease-causing genes, known as Bzw2 and Eif5a2, have been implicated in early prostate cancer ...

Funded by Prostate Cancer UK, the ICR team focused on genes involved in the PI3K-AKT pathway, which is frequently mutated in ...

In short, preclinical models may not necessarily permit the detection of context-specific activation of PI3K (or other effectors) by mutant KRAS. Tissue specimens from patients treated with KRAS ...

In a paper published in Science Bulletin, a Chinese team of scientists reported a comprehensive proteogenomic analysis of 101 Chinese AML patients, including proteomic and phosphoproteomic analyses ...

Depression continues to grapple a large proportion of the population. Given the side effects associated with the long-term use of conventional antidepressants, there is a need for novel rapid acting ...

Next, researchers analyzed the mTOR signaling-related protein activation in brain regions ... anti-depressive effect was produced through the PI3K and mTOR pathway. The IL-PFC in rodents is ...

More information: Toshinori Yoshioka et al, Delta opioid receptor agonists activate PI3K–mTORC1 signaling in parvalbumin-positive interneurons in mouse infralimbic prefrontal cortex to exert ...

In fact, exercise stimulates the release of EVs enriched with irisin, miR-486-5p, and miR-342-5p from SKM; this result in the activation of protective networks within the cardiovascular system, ...

Aspirin use in patients with PI3K-mutated colorectal cancer helped to reduce disease recurrence, highlighting the importance ...

Low-dose aspirin significantly reduced risk for colorectal cancer recurrence among patients with mutations in the PI3K ...

Aspirin has been shown to effectively reduce recurrence rates and improve disease-free survival,” said Anna Martling, MD, PhD.