Taking an antihistamine like Benadryl (diphenhydramine) can also help. Long-term, the best way to stop the itch is to figure out what's causing it. Long-term, the best way to stop the itch is to ...

Researchers are not sure why antihistamines stop working. Most evidence shows that drug tolerance does not happen no matter how long or aggressively the medications are used. If anything, prolonged ...