Two newly identified disease-causing genes, known as Bzw2 and Eif5a2, have been implicated in early prostate cancer ...

A group of such cells, called disease-associated hepatocytes (daHeps), showed NRF2 and AKT activation ... Intriguingly, the mutations observed in MASH-induced HCC are indicative of single-stranded ...

Funded by Prostate Cancer UK, the ICR team focused on genes involved in the PI3K-AKT pathway, which is frequently mutated in ...

AstraZeneca and Daiichi Sankyo’s Enhertu (trastuzumab deruxtecan) has been approved in the US for the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, ...

This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

The hypothalamic–pituitary–thyroid axis plays a crucial role in the pathogenesis, diagnosis, risk stratification, effectiveness of radioiodine therapy, and treatment response evaluation in epithelial ...

Panel B describes the refined model of KRAS activation informed by the effects of emerging KRAS inhibitors. According to this model, mutant KRAS is able to hydrolyze guanosine triphosphate (GTP ...

Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor ...

The pair had helped identify a still-unnamed disease, which they had tied to a particular gene and to a particular somatic mutation—a genetic change that had not been passed down from a parent ...

My wife and I have been married for over 12 years. We love each other and have a good sex life. She is beautiful and I cannot keep my hands off of her. I like to go down on her, I have always ...