How actin wavefronts rescue T cell receptors from endocytosis

Every time our body encounters a new disease-causing agent, a crucial defense system called adaptive immunity comes into play ...
Labroots

A Novel Mechanism by Which Melanoma Cells Evade the Immune Response Identified

The anti-tumor immune response involves a series of complex steps mediated by various immune cells and signaling molecules.

CAR T cells with boosted BACH2 protein can fight cancer more effectively

UT Southwestern Medical Center researchers have discovered that increasing the levels of a protein called BACH2 makes ...
The American Journal of Managed Care

What Would Make Therapy Last? How About 2 Targets Each on B Cells and T Cells?

The CEO of ModeX Therapeutics discusses MDX2003, a groundbreaking tetraspecific therapy that promises enhanced efficacy and ...
Frontiers

Autoimmune Diseases: from molecular mechanisms to therapy development

Autoimmune diseases arise when the immune system mistakenly targets and damages the body’s cells and tissues as though they ...
The Malaysian Reserve

FDA Grants Orphan Drug Designation to Cellenkos’ CK0804 Treg Therapy for Treatment of Myelofibrosis

CK0804 is a first in class, CXCR4hi Treg therapeutic designed to preferentially traffic towards its ligand CXCL12 over expressed in the bone marrow and ...
Healio

Rheumatologists view CAR T-cell therapy as ‘revolutionary,’ but cost, safety temper enthusiasm

Although rheumatologists consider chimeric antigen receptor T-cell therapy “potentially transformative,” nearly 70% remain ...
Targeted Oncology

CD19 CAR-NK Cell Therapy Yields Complete Responses in Waldenstrom NHL

Early results from the ongoing QUILT-106 clinical trial (NCT06334991) show that the treatment combination of CD19 chimeric antigen receptor natural killer (CAR-NK) cells with rituximab (Rituxan) can ...