The field of cellular immunotherapy has undergone a profound transformation in recent years, with autologous chimeric antigen receptor (CAR) T-cell therapies emerging as the standard-of-care option ...

Over the past decade, several novel immunotherapies have transformed the treatment landscape of relapsed or refractory B-cell acute lymphoblastic leukaemia. In the pivotal TOWER trial, blinatumomab—a ...

In contrast to other B‐cell antigen receptor (BCR) classes, the function of IgD BCR on mature B cells remains largely elusive as mature B cells co‐express IgM, which is sufficient for development, ...

Systemic lupus erythematosus (SLE) is characterised by numerous abnormalities in B lineage cells, including increased CD27++ plasmablasts/plasma cells, atypical CD27-IgD- B cells with increased CD95, ...

Moreover, B-cell depletion also reduced activation and proliferation of DCs and CD4 + T cells, which was associated with decreased IFN-γ but increased IL-17 production. 210 Transfer of purified B-2 ...

Moreover, B-cell depletion also reduced activation and proliferation of DCs and CD4 + T cells, which was associated with decreased IFN-γ but increased IL-17 production. 210 Transfer of purified B-2 ...

Demethanation Trend of Hydrochar Induced by Organic Solvent Washing and Its Influence on Hydrochar Activation. ... Pseudo-second-order models, GC–MS spectrum, surface area, Van Krevelen diagram, FTIR ...

A critical component of antibody generation is the T-dependent (TD) activation of naive B-cells in secondary lymphoid organs, which depends on two distinct signals: B-cell receptor (BCR) engagement by ...

Artificial nanostructured surfaces mimicking natural cell environments enhance CAR T-cell activation, longevity, and potency by promoting the generation of central memory T cells.