gut.bmj5d
Reparative immunological consequences of stem cell transplantation as a cellular therapy for refractory Crohn’s disease
Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain ...
eLife5d
A Commander-independent function of COMMD3 in endosomal trafficking
Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradatio ...
The EMBO Journal9d
Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation
In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...
eLife10d
Synthetic gene circuits that selectively target RAS-driven cancers
This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...
C&EN14d
NQO1-Activatable Circular Antisense Oligonucleotides for Tumor-Cell-Specific Survivin Gene Silencing and Antitumor Therapy
State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center and School of Pharmaceutical Sciences, Peking University, No. 38, Xueyuan Rd, Beijing 100191, China ...
GitHub18d
A modern diagram scripting language that turns text to diagrams.
In addition to being a runnable CLI tool, D2 can also be used to produce diagrams from Go programs. For examples, see ./docs/examples/lib. This blog post also demos a complete, runnable example of ...
C&EN18d
Spatial Control of CAR T Cell Activation Using Tumor-Homing Polymers
Department of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15th Avenue NE, Box 355061, Seattle, Washington 98195, United States Seattle Children’s ...
Nature19d
Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling
Downstream of the pre-BCR, SYK (spleen tyrosine kinase) has a central role in the activation of pathways that regulate the proliferation and differentiation of pre-B cells. In the context of ...
BMJ19d
Salivary gland epithelial cells from patients with Sjögren’s syndrome induce B-lymphocyte survival and activation
Salivary gland epithelial cells (SGECs) could play a role in promoting B-lymphocyte activation within the target tissue. We aimed to study the interactions between SGECs from patients with pSS or ...
BMJ19d
CD19-CAR T-cell therapy induces deep tissue depletion of B cells
The efficacy of CD19-CAR T-cell therapy is presumably based on deep tissue depletion of B cells; however, such effect has not been proven in humans in vivo. Methods Sequential ultrasound-guided ...
gut.bmj19d
Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection
3 German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany 4 Computational Biology for Individualised Medicine, ...
The Lancet19d
Senescent T cells: a potential biomarker and target for cancer therapy
1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...