During the 2019 pandemic sweeping through hospitals, an insidious companion emerged in bloodstream infections, where bacteria ...

The biochemical properties of CMY-32, a class C enzyme possessing a single-amino acid substitution in the Ω loop (Gly214Glu), were compared to those of the parent enzyme, CMY-2, a widespread class C β ...

In this clinical study, the MIC 90 for MRSA was 0.5 µg/ml and that for MSSA, 0.25 µg/ml; ceftaroline inhibited 100% (87 of 87) of Gram-positive isolates and 92.0% (23 of 25) of Gram-negative ...

Limited treatment options exist to combat infections caused by multidrug-resistant (MDR) Gram-negative bacteria possessing broad-spectrum β-lactamases. The design of novel β-lactamase inhibitors is of ...

Ceftaroline fosamil was approved in 2010 for the treatment of ABSSSIs and community-acquired bacterial pneumonia. Currently, ceftaroline is the only US FDA-approved cephalosporin available for the ...