Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China Fujian Key Laboratory of Drug Target ...

Conformational Design plays a key role in the medicinal chemistry of small molecule drug candidates. The emergence of generative AI models to assist molecular design and free-energy-perturbation ...

In the current study, the researchers used what is known as fragment-based drug design instead. The method involves first identifying a very small molecule that can bind to the target protein.

Fragment-based drug design (FBDD) has emerged as a powerful strategy in drug discovery, offering a complementary approach to traditional high-throughput screening (HTS)-based drug discovery. Over ...

Understand the decisions to approve or deny the sale of drugs and medical devices in Canada. Research whether a submission for a new drug or a new use for an approved drug has been accepted for review ...