Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradatio ...

Exosomes, the small extracellular vesicles secreted by nearly all cell types, have emerged as powerful players in intercellular communication and potential biomarkers for disease diagnosis and therapy ...

First, the authors showed that, after entering endosomes, PEI induces endosomal membrane damage and recruits LC3C, an essential protein in the formation of autophagosome. Next, they assessed ...

A team led by UT Southwestern Medical Center researchers has identified a key mechanism responsible for endosomal recycling in cells, a process critical to human health. Their findings, published in ...

Giamundo et al. present fundamental data with new insights into the role of Ezrin, a major membrane-actin linker that assembles signaling complexes, in the spatial regulation of EGF signaling ...

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

These unique, branched molecules help LNPs break through the endosomal membrane, making them more effective at delivering mRNA and gene-editing tools. In a recent study in Nature Communications ...

These unique, branched molecules help LNPs break through the endosomal membrane, making them more effective at delivering mRNA and gene-editing tools. In a recent study in Nature Communications ...

RSV infection proceeds by fusion of the viral envelope with the target cell membrane, but it is unclear whether fusion occurs with plasma or endosomal membranes. Entry and/or infection was studied in ...