A four year-long research study has found that particles secreted by an intestinal worm may assist in treating inflammatory ...

Peripheral tolerance occurs in secondary lymphoid organs (i.e., lymph nodes and spleen) and regulates the activation of nave T-cells via two mechanisms: anergy and regulatory T-cells. Anergy ...

The Nr4a family of nuclear receptors has been implicated in thymocyte central tolerance via clonal deletion and regulatory T cell induction ... and contribute to an anergy-like transcriptome ...

thus blocking the second activating signal for T-cell activation and resulting in anergy and clonal tolerance of T cells, which also block DC differentiation and become immune tolerogenic cells. More ...

Explore how T cell engagers could transform cancer and autoimmune treatments through promising trials and key collaborations.

The FDA has accepted an investigational new drug application for ALLO-329, an allogeneic chimeric antigen receptor T-cell ...

Researchers sought to determine whether the CAR-T therapy volamcabtagene durzigedleucel (CTX130) would be effective in patients with T-cell lymphoma.

Developing effective treatments and understanding how the mechanism of the immune system have always been challenging for ...

The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering ...

Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation -- and relocation -- as they fight infections in the small intestine.