Stroke is the second‐leading cause of death globally and ischemic stroke constituted more than 60% of all incident strokes in 2019. 1 Intravenous alteplase thrombolysis was approved by the US Food and ...

Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific evidence into clinical practice guidelines (guidelines) with recommendations to ...

Valvular repair or replacement is a common final management option in both primary and secondary MR, resulting in ≈50 000 annual mitral valve operations in the United States; however, defining the ...

As early as 1699, Chemineau described a heart composed of 2 auricles but only 1 ventricle.1 The univentricular heart has since fascinated the medical community. Unique in its complexity and scope, the ...

Aim: This executive summary of the clinical practice guideline for the evaluation and diagnosis of chest pain provides recommendations and algorithms for clinicians to assess and diagnose chest pain ...

Adenoviruses are typically associated with mild respiratory infections, but are increasingly attributed to cardiac infection. Viruses have long been understood to infect the heart, with many studies ...

The central antihypertensive action of clonidine was established by Sattler and van Swieten 1 in 1967. In their report, they described how this α 2 -adrenergic agonist produced a depressor effect when ...

A comprehensive literature search was conducted from September 14, 2022, to November 22, 2022, encompassing studies, reviews, and other evidence on human subjects that were published in English from ...

Beginning in this issue of Circulation, we present two new features designed to enhance the transfer of information to our clinician readers. First, you will notice that the cover includes a new box ...

Atrial fibrillation (AF), the most common sustained arrhythmia, represents a difficult scientific challenge and remains enigmatic even after more than a century of research. Already about a 100 years ...

Background— The relationship of circulating levels of high-sensitivity C-reactive protein (CRP) with cardiovascular disease (CVD) risk, particularly with consideration of effects at intermediate ...