Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's ...

Other Phenotypes Premature death, attributed to hindbrain tauopathy, generally occurs between eight and 12 months (Dutschmann et al., 2010). Premature death is preceded by weight loss, hyperkyphosis, ...

Findings The presence of three copies of chromosome 21, which harbors the amyloid precursor protein (APP) gene, is the most common genetic cause of Alzheimer’s disease. Carriers of this alteration ...

Massage might help your brain flow regain its mojo. On June 4 in Nature, researchers led by Gou Young Koh at the Institute for Basic Science in Daejeon, South Korea, mapped the labyrinth of lymphatics ...

To narrow down the number of scents needed for such a test, Li first ranked each of the 16 SST-ID and 40 UPSIT scents for their ability to distinguish PD/DLB from controls in three cohorts—the De Novo ...

Glymphatic clearance, which relies on a network of astrocytic endfeet arranged along vessels of the cerebrovasculature, has been implicated in AD, though it is not without controversy. Perivascular ...

In a healthy brain, border-associated macrophages within the dura mater and choroid plexus are replaced by circulating monocytes, while those in the leptomeninges and perivascular spaces, and also ...

To find out, Parhizkar gave lemborexant to P301S/E4 mice, which express human mutant tau along with human ApoE4, a risk factor for AD (Apr 2017 conference news). In this model, tau tangles begin to ...

Monocyte-derived microglia arise from hematopoietic stem cells, which divide throughout a mammal’s lifetime to generate monocytes. Over time, these stem cells accrue mutations, for example in DNM3TA, ...

What’s more, the annexin shrank these neurites, as seen by a reduction in the amount of LAMP1, a lysosomal protein that packs into these membrane swellings. The size or number of amyloid plaques ...

To report consequences on AD research, Alzforum has spoken with scientists across the board, including some whose research has been subject to funding cuts, as well as some who have so far remained ...