The human brain develops over decades, making this process notoriously difficult to model in a dish. Now, scientists have taken a step toward this goal. As described in preprint posted October 2 on ...

Synonyms: High-copy SOD1-G93A, B6SJL.SOD1-G93A, Tg(hSOD1-G93A)1GUR mice, Gurney mice ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

In a new proteomics extravaganza, scientists have unearthed groups of proteins that appear to be at the heart of Alzheimer’s disease pathogenesis. As described in Cell on September 25, scientists led ...

Doctor of Philosophy (PhD) University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology Graduate Certificate in Public Health Preparedness and ...

This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, ...

Scientists have uncovered a potential new mechanism whereby α-synuclein pathology spreads. Like black holes, large densities of α-synuclein pull in surrounding matter. Among the victims trapped in ...

Cellular aging is a central feature of neurodegenerative diseases, and microglia, the brain’s resident immune cells, are especially susceptible. Alas, whether this reflects intrinsic wear and tear or ...

Could a single nucleotide switch safeguard decades of brain health before Alzheimer’s sets in? Researchers know that this is what the rare apolipoprotein E3 Christchurch variant does, but how it pulls ...

With several antibodies to mop up amyloid plaques coming into routine use, the big challenge for scientists has become to find ways to temper tau pathology. Two different studies report some news on ...