Xenobiotics like drugs are recognised as key influencers of gut bacterial growth. Yet, their impact on the production of metabolites involved in microbiota–host interactions is largely unknown. Here, ...

imageimageThere are no cellular or molecular biomarkers diagnostic of myalgic encephalomyelitis (also known as chronic fatigue syndrome [ME/CFS]). We find hundreds of blood-based traits are different, ...

The study explores the transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters.

FANCM employs a sophisticated dual recognition mechanism in genome maintenance, using distinct DNA-binding domains to identify and move around on branched DNA structures. This study reveals how FANCM ...

Algorithms that constrain metabolic network models with enzyme levels to predict metabolic activity assume that changes in enzyme levels are indicative of flux variations. However, metabolic flux can ...

Pro-inflammatory macrophage activation is a hallmark example of how mitochondria serve as signaling organelles. Oxidative phosphorylation sharply decreases upon classical macrophage activation, as ...

imageimageThis study identifies a pathway for oxidation and assembly of mitochondrial inner membrane proteins. Dbi1 is a conserved mitochondrial inner membrane protein that interacts with the ...

imageimageEBNALP alters looping factor YY1 DNA binding and 3D genome organization which might facilitate cell cycle progression and prevent cell death. EBNALP is tethered to DNA by DPF2. EBNALP ...

Nipah virus is a highly virulent zoonotic paramyxovirus causing severe respiratory and neurological disease. Despite its lethality, there is no approved treatment for Nipah virus infection. The viral ...

How loss of KIF4A chromokinesin reduces chromosome association of condensin has remained unclear. This study demonstrates that human condensin I is auto-inhibited by short linear motifs (SLiMs) in its ...

Live imaging of secretory cargoes is a powerful method for understanding the mechanisms of membrane trafficking. Inducing the synchronous release of cargoes from an organelle is key for enhancing ...

Gpr54 deletion lowers NFATC3 and SFRP1 levels, activates the Wnt/β-catenin pathway, which stimulates DPCs and HFSCs, and accelerates hair cycle and hair regeneration.