Nature Medicine - Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells Skip to main content Thank you for visiting nature.com.

A model developed by LMU biophysicists demonstrates how biological processes form the convoluted internal architecture of the ...

Immune checkpoint pathways regulate T cell function and play pivotal roles in the treatment of both cancer and autoimmune ...

These include DNAM-1 and NKG2D, which detect autoreactive T cells. Song added that the cells also crank up CXCR3, a chemokine receptor that eases passage into the brain—and shows up frequently in ...

I would be surprised if there weren’t diseases where T cell targeting, particularly eliminating activated autoreactive T cells, would not be an additional benefit to the patient. Zach Roberts: ...

Studies suggest that vitamin D deficiency can lead to an overproduction of autoreactive T cells, which mistakenly target the body’s own tissues, contributing to autoimmune conditions like ...

Holding these trigger-happy troops back during peacetime falls to a sparse population of regulatory T cells, according to a paper published January 28 in Science Immunology. ... with recent work from ...

Study uncovers a pathogenic subset of memory T-cells that promote tissue inflammation and highlights a potential target for treating nasal polyps and other inflammatory airway diseases. Study ...

Under terms of the deal, AbbVie will acquire Capstan’s lead asset, CPTX2309—an in vivo anti-CD19 CAR T-cell therapy in Phase ...

Seven MIS-C patients had autoreactive T cells against SNX8-expressing cells, but none of the at-risk controls possessed autoreactive T cells. In addition, MIS-C patients also had T cells cross ...

These CAR-T cells are then given to patients and dock onto damaging autoreactive B cells in their blood and destroy them. This results in a "reboot" for the immune system.