For starters, she pointed out that standard CAR-T therapy involves a lymphodepletion regimen with cyclophosphamide and ...

A recent study published in the journal Nature evaluated differential autoreactivity to human and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteomes in SARS-CoV-2-infected children ...

Summary of the research: This study revealed that T cells can discriminate between self- and neoself- antigens, and that neoself-reactive T cells are involved in causing autoimmune diseases. Osaka, ...

It is well known that the biggest genetic risk factor for the autoimmune disease systemic lupus erythematosus (SLE) is major histocompatibility complex class II (MHC-II). What remains unclear is the ...

In a discussion hosted by Dr. Zachary Roberts, Executive Vice President of R&D and Chief Medical Officer at Allogene Therapeutics, leading rheumatologists Dr. Chris Wincup of King’s College Hospital ...

Autoimmune diseases share the same core pathology despite their differing clinical manifestations: dysregulated B and T cell activity. B cells contribute to disease progression by secreting ...

Activation of certain memory B cells may be driving systemic lupus erythematosus incidence in individuals who had ...