Immune checkpoint pathways regulate T cell function and play pivotal roles in the treatment of both cancer and autoimmune ...

Scientists say they have very strong evidence that the adult human brain is capable of making new neurons, a point of ongoing controversy in neuroscience.

Scientists have found evidence of new brain cells sprouting in adults - a process that many thought only occurred in children ...

Researchers in Japan have successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse ...

As part of the deal, AbbVie will acquire Capstan's targeted LNP platform technology and its lead candidate for B cell-mediated autoimmune diseases.

Thymic crosstalk between T cells and the thymus during T-cell priming shapes how the thymus grows and shapes itself.

Mansi Shah, MD, explains how treatment sequencing and patient eligibility guide the use of these therapies in multiple ...

We used these tools to serially stimulate primary polyclonal T cells and make autoreactive T cell hybridomas. We then cloned the TCRs of these hybridomas into retroviral vectors to make “retrogenic ...

Table 2. Representative clinical trials for CAR-T cell therapy in autoimmune diseases Despite promising results in SLE, challenges remain in applying CAR-T therapy to other autoimmune diseases. In ...

Cytotoxic T cells are star players in the adaptive immune system, enforcing protection against invading viruses or cancer cells. However, evidence has been mounting that the cells may also deal a ...

I would be surprised if there weren’t diseases where T cell targeting, particularly eliminating activated autoreactive T cells, would not be an additional benefit to the patient.