Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain ...

Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradatio ...

This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

In addition to being a runnable CLI tool, D2 can also be used to produce diagrams from Go programs. For examples, see ./docs/examples/lib. This blog post also demos a complete, runnable example of ...

Department of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15th Avenue NE, Box 355061, Seattle, Washington 98195, United States Seattle Children’s ...

Downstream of the pre-BCR, SYK (spleen tyrosine kinase) has a central role in the activation of pathways that regulate the proliferation and differentiation of pre-B cells. In the context of ...

Salivary gland epithelial cells (SGECs) could play a role in promoting B-lymphocyte activation within the target tissue. We aimed to study the interactions between SGECs from patients with pSS or ...

The efficacy of CD19-CAR T-cell therapy is presumably based on deep tissue depletion of B cells; however, such effect has not been proven in humans in vivo. Methods Sequential ultrasound-guided ...

3 German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany 4 Computational Biology for Individualised Medicine, ...

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

B-cell prolymphocytic leukemia (B-PLL) is a rare, aggressive type of leukemia that progresses rapidly. People with B-PLL typically have a less favorable outlook. However, new targeted treatments ...

For the 12th straight year, the Bruins have granted "Behind The B" cameras unprecedented access into the team's locker room, executive boardroom, and players' homes that will give fans a behind ...