ImmunityBio has gained US Food and Drug Administration (FDA) authorisation for an expanded access programme to supply an ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Cellistic, a pioneer in iPSC-based off-the-shelf cell therapy development and manufacturing services, announces the launch of its Allo Chassis-ready-to-use, immune-cloaked iPSC cell lines derived from ...

Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic ...

A personalized neoantigen cancer vaccine generated strong immune responses in renal cell carcinoma patients, leading to ...

Interleukins are cytokines produced and secreted mainly by CD3+ and CD4+ T lymphocytes. Interleukins promote development and differentiation of natural killer cells, T and B lymphocytes and ...

We next analysed the overlaps between different cytokine-producing T cell subsets. The majority of GM-CSF-producing CD4 T cells in PB did not produce other cytokines (figure 1A, C). They could thus be ...

Natural arising CD4+ regulatory T cells (Tregs) play a critical role in maintaining peripheral tolerance by suppressing inflammation and preventing autoimmune responses in SLE. Additionally, CD8+ ...

Over the past few decades, scientific research has helped us reveal that innate and adaptive immune cells contribute to the chronic inflammatory pathological process of psoriasis. In particular, ...

Pharmacologic or genetic inhibition of PGAM inhibited Treg differentiation and shifted CD4 T cells toward a pro-inflammatory, Th17-like state. Mechanistically, we found that PGAM regulates Treg ...