Ceftaroline fosamil was approved in 2010 for the treatment of ABSSSIs and community-acquired bacterial pneumonia. Currently, ceftaroline is the only US FDA-approved cephalosporin available for the ...

In this clinical study, the MIC 90 for MRSA was 0.5 µg/ml and that for MSSA, 0.25 µg/ml; ceftaroline inhibited 100% (87 of 87) of Gram-positive isolates and 92.0% (23 of 25) of Gram-negative ...

Abstract and Introduction The emergence of new human pathogens and increasing antimicrobial resistance in well-established pathogens are critical public health concerns. Unfortunately, the pipeline of ...

In addition to methicillin, strains of S. aureus have developed resistance to other antibiotics. MRSA is resistant to cephalosporins, erythromycin, clindamycin (Cleocin ®), gentamycin, ...

Antibiotic resistance frequently results in delayed adequate antibiotic treatment, increasing morbidity and mortality. AMR is the inherited ability of microorganisms to grow at high antibiotic ...

The biochemical properties of CMY-32, a class C enzyme possessing a single-amino acid substitution in the Ω loop (Gly214Glu), were compared to those of the parent enzyme, CMY-2, a widespread class C β ...

Limited treatment options exist to combat infections caused by multidrug-resistant (MDR) Gram-negative bacteria possessing broad-spectrum β-lactamases. The design of novel β-lactamase inhibitors is of ...

Objective Amoxicillin-clavulanate is commonly used to prevent infections following snakebites despite the lack of clinical evidence. We aimed to demonstrate that clinically directed initiation of ...