The Blood-Horse

OwnerView Webinar Looks at Foal Conformation

The ninth installment in the 2025 OwnerView webinar series was held Nov. 12 and featured a veterinarian from Rood & Riddle Equine Hospital discussing foal conformation and possible corrections. Gary ...
eLife

Expanding automated multiconformer ligand modeling to macrocycles and fragments

The work presents a valuable extension of qFit-ligand, a computational method for modeling conformational heterogeneity of ligands in X-ray crystallography and cryo-EM density maps. The authors ...
C&EN

Rapid Access to Small Molecule Conformational Ensembles in Organic Solvents Enabled by Graph Neural Network-Based Implicit Solvent Model

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Understanding and manipulating the conformational behavior of a molecule in different ...
GEN

Generative AI Model, ChromoGen, Rapidly Predicts Single-Cell Chromatin Conformations

Every cell in a body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These cell-specific gene expression patterns, which ensure that a brain cell is different ...
JSTOR Daily

Agonist concentration–dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 31 (August 2, 2022), pp. 1-8 (8 pages) The bacteria-derived formyl peptide fMet-Leu-Phe (fMLF) is a ...
eLife

Conformational dynamics of a nicotinic receptor neurotransmitter site

This useful work provides insight into agonist binding to nicotinic acetylcholine receptors, which is the stimulus for channel activation that regulates muscle contraction at the neuromuscular ...
Frontiers

The conformation of the nSrc specificity-determining loop in the Src SH3 domain is modulated by a WX conserved sequence motif found in SH3 domains

Department of Chemistry, Western Washington University, Bellingham, WA, United States Cellular signaling networks are modulated by multiple protein-protein interaction domains that coordinate ...
EurekAlert!

A crown-ether-decorated metal-organic framework enables rapid extraction of trace benzene from cyclohexane

(a) Comparison of binding of benzene molecules in quadrangular, triangular and circular channels. (b) Side view of the one-dimensional coordination chain. (c) Coordination mode of ligand. (d) View of ...
EurekAlert!

USTC develops deep learning model to predict protein conformational changes

Recently, the research team of Prof. WANG Qian from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) and Prof. BAI Fang from ShanghaiTech University ...