These unique, branched molecules help LNPs break through the endosomal membrane, making them more effective at delivering mRNA and gene-editing tools. In a study in Nature Communications ...

How is plasma membrane protein composition controlled? There are several control mechanisms, most of which depend on endosomal trafficking pathways. Plasma membrane proteins reach the endosomes by ...

Exosomes, the small extracellular vesicles secreted by nearly all cell types, have emerged as powerful players in intercellular communication and potential biomarkers for disease diagnosis and therapy ...

Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradatio ...

First, the authors showed that, after entering endosomes, PEI induces endosomal membrane damage and recruits LC3C, an essential protein in the formation of autophagosome. Next, they assessed ...

Researchers at UT Southwestern identified how SNX17 and Retriever interact to regulate endosomal recycling, a crucial process for protein transport. Using cryo-EM imaging, they revealed a key binding ...

A team led by UT Southwestern Medical Center researchers has identified a key mechanism responsible for endosomal recycling ... back to the plasma (cell) membrane," said Emre Turer, M.D., Ph.D ...