Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...

RFdiffusion2, RFdiffusion3, and Riff-Diff each solve different structural problems in computational enzyme design ...

Proteins that respond to external stimuli function as molecular switches, playing a vital role in the precise regulation of biological processes. Therefore, if protein switches could be artificially ...

Enzymes are vital to metabolism and drive countless biological processes in humans, plants, and industry. Yet, when overwhelmed by excess substrate, some enzymes slow down — a phenomenon known as ...

A new method that successfully designs serine hydrolase enzymes capable of catalyzing ester hydrolysis with high efficiency, demonstrates a computational approach for creating de novo enzymes that ...

As the coronavirus disease 2019 (COVID-19) pandemic continues to infect people worldwide, specific pharmaceutical interventions have been found to be few. As the logistics of mass vaccination are ...