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The full data also identifies chains by segment, so here we’ve broken out the 10 biggest full-service Italian and pizza restaurants by U.S. systemwide sales, out of 38 that appear on the list.

4. Buca di Beppo. Buca di Beppo chains have been around since 1993 and now have 96 locations in the US. Recipes are inspired by Northern and Southern Italian cuisine. 3. Romano's Macaroni Grill.