Thus, the role of other immune responses, including those mediated by natural killer (NK) cells, must be considered in HDV pathogenesis and in treatments with immune-stimulating agents such as ...

While the concentration of conventional interferon peaks and then declines rapidly after subcutaneous administration, the serum concentration of pegylated interferon increases gradually and does ...

These changes in immune responses were regulated by type-1 interferons (IFN-1), an immune signaling molecule. Blocking the IFN-1 receptor protein in mice suppressed these immune responses and lowered ...

BESREMi® (ropeginterferon alfa-2b) is a long-acting, mono-pegylated proline interferon (ATC L03AB15). It is administered once every 2 weeks initially, or up to every 4 weeks after stabilization ...

The interferon (IFN) family of proteins plays key roles in the immune response against viruses and other pathogens. In the context of COVID-19, IFNs have been shown to be key for restraining ...

More recently, pegylated drugs for the treatment of hepatitis ... of Intron-A causes peaks and troughs in blood levels of interferon. In comparison, once-weekly administration of PegIntron ...

Background: Hepatitis B surface antigen (HBsAg) loss, namely, the functional cure, can be achieved through the pegylated interferon (PEG-IFN)-based therapy. However, it is an unignorable fact that a ...

Interferon-alpha (IFN-α) is a cytokine widely used in the treatment of brain cancers and virus infections with side effects including causing depression. Monoamine neurotransmitter systems have been ...

Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain ...

Interferon (IFN) inhibits HIV replication by inducing antiviral effectors. To comprehensively identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of Interferon Stimulated ...