Viral proteases, the key enzymes that regulate viral replication and assembly, are promising targets for antiviral drug discovery. Herpesvirus proteases are enzymes with no crystallographically ...

Background: Glutamine is required for the growth and survival of multiple tumor types. CB-839 is a highly selective, reversible, allosteric inhibitor of glutaminase, a choke point in the utilization ...

Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and ...

Machine learning helps improve accuracy and efficiency of small-molecule calculations Microsoft researchers used deep learning to create new DFT model by Sam Lemonick, special to C&EN June 20, 2025 ...

Scientists have identified that the molecule cardiotrophin-like cytokine factor 1 (CLCF1) surges through the bloodstream during workouts, particularly resistance training. This protein appears to ...

With PMDA approval now secured in Japan, MedHub-AI is progressing rapidly toward regulatory clearance in the United States. The company is in the final stages of its FDA 510k process and expects ...

Several distinct spectral lines aligned precisely with those of the aromatic molecule, confirming its presence with strong statistical significance. The seven ring polycyclic aromatic hydrocarbon (PAH ...

It is now known, thanks to recent studies, that the molecule hevin (or SPARCL-1) may be the key to preventing cognitive decline. Hevin is a protein naturally produced in the brain by cells called ...

Biohybrid molecule uses light-driven electrons to efficiently produce hydrogen by Ruhr University Bochum edited by Lisa Lock, reviewed by Robert Egan Editors' notes ...

Abstract: Existing drug discovery pipelines take 5–10 years and cost billions of dollars. Computational approaches aim to sample from regions of the whole molecular and solid-state compounds called ...

A new molecule developed by UB researchers acts like a local, long-lasting anesthetic, providing robust pain relief for up to three weeks, according to the results of preclinical studies reported ...

Designing new molecules is essential for drug discovery and material science. Recently, deep generative models that aim to model molecule distribution have made promising progress in narrowing down ...