A recent study published in Genes & Diseases reveals new insights into the relationship between immune cell characteristics, ...

A recent study published in Genes & Diseases reveals new insights into the relationship between immune cell characteristics, ...

This is the first-in-human phase 1/2a trial of Treg and bone marrow transplantation in HLA-mismatched living donor kidney transplant recipients.

A chronic hepatitis B (CHB) infection is characterised by host immune dysfunction related to a high viral antigen load. The restoration ...

In vivo EGL-001 preferentially bound to the surface of Tregs due to their high CTLA-4 and CD25 expression and depleted them from the tumor microenvironment without affecting other immune cells.

Egle Therapeutics unveils preclinical biodistribution data on EGL-001, a novel anti-CTLA4-IL2 mutein fusion antibody designed to selectively deplete tumor-infiltrating regulatory T cells (Tregs).

These findings provide key insights into the complex biological functions of Treg cell V (D)J recombination, tolerance selection, development, and migration. Introduction The discovery of CD4+CD25+ ...

Other markers can be used to functionally characterize the Treg cell group such as CTLA4, CD45RA, Helios, and the intensity of expression of FOXP3. The Treg cells can be divided into subgroups as ...

AMG 592 caused robust, dose-dependent Treg expansion relative to Tcon in all treated individuals. Expanded Tregs had increased CD25 and FoxP3, and were enriched for recent thymic emigrants. At the ...

Hoffmann, et al. Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol 2009; 39 (4): 1088-1097.