The actress, who stars alongside Demi Moore in the body horror film, says it took "probably a year" for her skin to recover.

Margaret Qualley says her skin went through a lot while filming 'The Substance.' On Josh Horowitz’s 'Happy Sad Confused' podcast, the actress opened up about the effects of wearing prosthetics for the film and how it impacted her skin.

During a recent appearance on the Happy Sad Confused podcast, Margaret Qualley revealed that the prosthetics she wore in "The Substance" "f--ked up" her skin, saying that it took "a year" for her skin to fully recover from the acne.

Adhesive materials, artificial skin, and layers of heavy makeup used to create these effects can often clog pores

Margaret Qualley is opening up about the long-lasting effects she suffered while filming for 'The Substance.' The actress, who plays Sue in the body horror film, recently shared on the Happy Sad Confused podcast that her skin was damaged for nearly a year after filming wrapped.

In The Substance, Hollywood star Elisabeth Sparkle (Demi Moore) is fired from her aerobics show when she turns 50. This leads her to seek out a drug called The Substance. After taking the drug, Elisabeth births a younger version of herself who she shares a consciousness with - the catch is she has to alternate living as each every seven days.

"It took me probably, like, a year to recover physically from all of it," she told a podcast about the prosthetics used in the film.

Margaret Qualley really felt the effects of “The Substance.” The actress, 30, recently appeared on Josh Horowitz’s “Happy Sad Confused” podcast and spoke about how wearing extensive prosthetics to shoot the bloody horror film took a toll on her skin.

In 'The Substance,' Margaret Qualley wore a mountain of facial prosthetics, which had a detrimental effect on her face.