⚡ Non-Selective COX Inhibitors (NSAIDs) 📍 Gastric toxicity: Block COX-1 - reduces protective gastric prostaglandins - causes peptic ulcers, bleeding, and perforation risk 📍Use PPI co-therapy in high-risk patients (elderly, H. pylori , prior ulcer) ⚡ Selective COX-2 Inhibitors (Coxibs) 📍 Gastroprotective: Spare COX-1 - preserve gastric mucosal protection - significantly lower risk of GI ulcers and bleeding compared to non-selective NSAIDs 📍 Cardiovascular risk: Inhibit COX-2-derived prostacyc
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